A group of enlightened citizens of Malleshwaram felt a need to open a college in Malleshwaram particularly to provide facilities to girl students, who had to go as far as Maharanis College for their courses in higher learning. The founders Sri.G.A.Acharya, Prof.B.R. Subba Rao, Sri. M.Chinnaswamy, Sri M.R.Narasimha Iyengar, Prof.M.P.L.Sastry and Smt Vimala Rangachar responded to this need by starting an intermediate college in 15th Cross, Malleshwaram, and started the institution in 1956-57 with a student strength of 68.
In 1962 courses in Science started. In the course of its historical development MES College has acquired great prominence not only in Karnataka but also in the country. The growth is both quantitative and qualitative. The college is now a four-floor stone structure with an annex to accommodate the growing strength of students. Spacious, well-lit and airy classrooms are most suited for effective learning and teaching. Anybody who enters this college will feel and experience the silken touch of care, compassion and concern, which embody the philosophy of learning pursued here. Consequently character, confidence and credibility evolve.
In its infant stages the college was housed in a small dwelling Anandashram, which recalled the ancient Guru Kula with a good rapport between the small number of students and their teachers. From this humble beginning the college has grown gradually into a full-fledged college.
MES has grown with its ideal of spreading academic culture in several ways. Its aim has always been to provide value based education at affordable cost and to strive for the cultural growth of the student. The college celebrated its Silver Jubilee in 1982 and its 40th year of meaningful functioning in 1997.
The main college was bifurcated according to the Karnataka Government order DCE|ROB|134|134|internal|2001-02 dated 7.8.2001 into MES Degree College of Arts, Commerce and Science and MES Pre-University College of Arts, Commerce and Science.
The two colleges have been working in the same campus.